FUSION Abstracts

American Diabetes Association 1996

• Ghosh, S., Ally, D., Hauser, E., Nylund, S., Valle, T., Watanabe, R., Eriksson, J., Bergman, R., Boehnke, M., Collins, F., and the FUSION team. The Beta 3 Adrenergic Receptor Codon 64 Variant is Not Associated With Age-at-Diagnosis of NIDDM Nor With Obesity in the FUSION (Finland-United States Investigation of NIDDM Genetics) Study. Diabetes 45(Suppl 2):A229, 1996.
• Tuomilehto-Wolf, E., Vidgren, G., Nyland, S., Hagopian, W.A., Valle, T., Kohtamaki, K., Boehnke, M., Collins, F.S., Ghosh, S., Tuomilehto, J. Genes for NIDDM in the HLA Region on Chromosome 6: The Finland- United States Investigation of NIDDM Genetics (FUSION). Diabetes 45(Suppl 2):A30, 1996.
• Watanabe, R.M., Hauser, E.R., Valle, T., Eriksson, J., Bergman, R.N., and Boehnke, M. for the Finland-United States Investigation of NIDDM Genetics (FUSION) Study Investigators. Familiality of Quantitative Metabolic Traits in a Finnish Population. Diabetes 45(Suppl 2):A77, 1996.

American Diabetes Association 1997

• Ghosh, S., Hauser, E.R., Magnuson, V.L., Ally, D.S., Valle, T., Watanabe, R.M., Nylund, S.J., Kohtamaki, K., Hagopian, W., Bergman, R.N., Tuomilehto, J., Collins, F.S., and Boehnke, M. for the Finland-United States Investigation of NIDDM Genetics (FUSION) Study. Multipoint Linkage Analysis of NIDDM in 534 Finnish Families in the FUSION Study. Diabetes 46:A76, 1997.

American Diabetes Association 1998

• Ghosh, S., Hauser, E.R., Magnuson, V.L., Valle, T., Watanabe, R.M., Ally, D., Erdos, M.R., Balow, J., Bergman, R.N., Tuomilehto, J., Collins, F.S., and Boehnke, M. for the Finland-United States Investigation of NIDDM Genetics (FUSION) Study. A Genome Scan on 709 Finnish Type 2 Diabetes Affected Sib Pairs Reveals Suggestive Evidence For Linkage On Chromosome 20q. Diabetes, 47(Suppl 1):A15, 1998.
• Watanabe, R.M., Langefeld, C.D., Valle, T., Tuomilehto, J., Ghosh, S., Collins, F.S., Bergman, R.N., and Boehnke, M. for the Finland- United States Investigation of NIDDM Genetics (FUSION) Study. Comparison with NIDDM Linkage Results for Chromosome 20. Linkage Analysis of NIDDM-Related Quantitative Traits in the FUSION Study. Diabetes 47(Suppl 1):A171, 1998.

American Diabetes Association 1999

• Ghosh, S., Hauser, E.R., Watanabe, R.M., Valle, T., Ally, D.S., Balow, J.E., Duren W., Tuomilehto, J., Collins, F.S., and Boehnke. M. Identification of Influential Subsets in 716 Finnish Affected Sibling Pairs Using Type 2 Diabetes-related Quantitative Trait Data. Diabetes 48(Suppl 1):A182, 1999.
• Watanabe, R.M., Langefeld, C.D., Epstein, M., Valle, T., Ghosh, S., Collins, F.S., and Boehnke, M. for the Finland-United States Investigation of NIDDM Genetics (FUSION) Study Investigators. Genome-Wide Linkage Analysis of Type 2 Diabetes-Related Quantitative Traits in the FUSION Study. Diabetes 48(Suppl 1):A46, 1999.

American Diabetes Association 2000

• Watanabe, R., Erdos, M., Douglas, J., Valle, T., Tuomilehto, J., Collins, F., and Boehnke, M. for the FUSION Study Group. Association of the Peroxisome Proliferator-Activated Receptor-PPAR Gamma PRO12ALA variant with Type 2 Diabetes-Related Phenotypes in a Large Finnish cohort. Diabetes 49(Suppl 1):A206, 2000.
• Zhou, Z., LaGasse, J., Valle, T., and Hagopian, W. Carboxypeptidase-H Autoantibodies Lack Sensitivity and Specificity for Diagnosis of Type 1 Diabetes but may be an Additional Immume Marker in Latent Autoimmune Diabetes of Adulthold (LADA). Diabetes 49(Suppl 1):A411, 200.

American Diabetes Association 2001

• Watanabe, R.M., Mohlke, K.L., Silander, K., Stringham, H.M., Valle, T.T., Tuomilehto, J., Collins, F.S., Bergman, R.N., and Boehnke, M. for the FUSION Study. Evidence for a Type 2 Diabetes Susceptibility Locus on Chromosome 6 in a Phenotypically Unique Subset of Finnish Subjects. Diabetes 50(Suppl 1):A248, 2001.

American Diabetes Association 2004

• Scott, L.J., Mohlke, K.L., Silander, K., Peck, E.C., Hollstein, P.E., Skol, A.D., Chines, P.S., Valle, T.T., Bergman, R.N., Tuomilehto, J., Watanabe, R.M., Collins, F.S., Boehnke, M. Non-coding SNPs Near and Within the Hepatocyte Nuclear Factor-4 Alpha Gene are Associated with Type 2 Diabetes in Finns.

American Diabetes Association 2005

• Bonnycastle, L.LO., Willer, C.J., Jackson, A.U., Conneely, K.N., Mohlke, K.L., Scott, L.J., Narisu, N., Chines, P.S., Erdos, M.R., Valle, T.T., Buchanan, T.A., Bergman, R.N., Tuomilehto, J., Watanabe, R.M., Boehnke, B., Collins, F.S. Type 2 Diabetes (T2D) and Quantitative Trait Association Analysis of a Finnish Sample with SNPs Previously Reported to be Associated with T2D.

American Diabetes Association 2008

• Watanabe, R.M., Chen, W-M., Erdos, M.R., Saxena, R., Jackson, A.U., Lyssenko, V., Uda, M., Schlessinger, D., Groop, L., Collins, F.S., Altshuler, D., Abecasis, G., Boehnke, M., and Scuteri, A. Novel Genetic Loci for Fasting Glucose and Insulin Identified by Genome-wide Association in Caucasians.

American Society of Human Genetics 1997

• Ghosh, S., Hauser, E., Magnuson, V., Valle, T., Ally, D., Watanabe, R., Hagopian, W., Bergman, R.N., Tuomilehto, J., Collins, F., and Boehnke, M., for the FUSION Team. The FUSION (Finland-United States Investigation of NIDDM Genetics Study. American Journal of Human Genetics 61(Suppl):A276, 1997.
• Watanabe, R.M., Hauser, E.R., Valle, T., Eriksson, J., Bergman, R.N., Ghosh, S., and Boehnke, M. for the Finland-United States Investigation of NIDDM (FUSION) Study Investigators. Familiality of Minimal Model-Derived Quantitative Metabolic Traits in a Finnish Cohort. American Journal of Human Genetics 61(Suppl):A300, 1997.

American Society of Human Genetics 1998

• Ghosh, S., Watanabe, R.M., Hauser, E.R., Magnuson, V.L., Valle, T. Erdos, M.R., Balow, J., Ally, D., Langefeld, C.D., Kohtamaki, K., Kaleta, H.S., Blaschak-Harvan, J., Tuomilehto-Wolf, E., Hagopian, W., Tuomilehto, J., Bergman, R.N., Collins, F.S., and Boehnke, M. for the Finland-United States Investigation of NIDDM Genetics (FUSION) Study. Evidence for Linkage on Chromosome 20 in 712 Finnish Type 2 Diabetic Sib Pairs and Exclusion of the HNF4alpha (MODY1) gene. American Journal of Human Genetics 63(Suppl):A44, 1998.
• Watanabe, R.M., Langefeld, C.D., Valle, T., Tuomilehto, J., Ghosh, S., Collins, F.S., Bergman, R.N., and Boehnke, M. for the Finland- United States Investigation of NIDDM Genetics (FUSION) Study. Comparison with NIDDM Linkage Results for Chromosome 20. Linkage Analysis of NIDDM-Related Quantitative Traits in the FUSION Study. American Journal of Human Genetics 63(Suppl):A313, 1998.

American Society of Human Genetics 1999

• Erdos, M., Braun, A., Mohlke, K., Silander, K., Ghosh, S., Collins, F.S. for the FUSION (Finland-US Investigation of NIDDM) study group. NHGRI, NIH, Bethesda, MD, Sequenom Inc., San Diego, CA. MALDI-TOF mass spectrometry for high throughput SNP detection: Application to type 2 diabetes.
• Watanabe, R.M., Langefeld, C.D., Epstein, M., Valle, T., Ghosh, S., Collins, F.S., Bergman, R.N., and Boehnke, M., for the FUSION Study Investigators. Genome-Wide Linkage Analysis of Type 2 Diabetes-Related Quantitative Traits in the FUSION Study. American Journal of Human Genetics 65(Suppl 1):A452, 1999.

American Society of Human Genetics 2000

• Chines, P.S., Silander, K., Narisu, N., Erdos, M.R., Voltz(2), A.K., Mohlke, K., Collins, F.S. DIR/GMBB, NHGRI, Bethesda, MD. (2)DIR/IDRB, NHGRI, Baltimore, MD. A simple, efficient procedure for mapping SNPs to genomic sequence.
• Erdos, M.R., Douglas, J.A., Watanabe, R.M., Braun, A., Oeth, P., Johnston, C., Mohlke, K., Valle, T., Buchanan, T.A., Bergman, R.N., Collins, F.S., Boehnke, M., Tuomilehto, J., and the FUSION Study Group. The PPAR Gamma Pro12Ala variant: association with type 2 diabetes, trait differences, and interaction with the Beta 3-adrenergic receptor. American Journal of Human Genetics 67(Suppl 1):A1997, 2000.
• Mohlke, K.L, Lange, E.M., Valle, T., Collins, F.S., and Boehnke, M. for the FUSION Study. Marker-marker Linkage Disequilibrium Extends Beyond 1 cM on Chromosome 20 in Finns. American Journal of Human Genetics 67(Suppl 2):A86, 2000.
• Silander, K., Watanabe, R., Valle, T., Mohlke, K., Stringham, H., Doheny, K., Pugh, E., Bergman, R., Tuomilehto, J., Collins, F., Boehnke, M., and the FUSION Study Group. Genome Scan Results of an Independent Set of Finnish Affected Sibling Pairs with Type 2 Diabetes. American Journal of Human Genetics 67(Suppl 1):A193, 2000.

American Society of Human Genetics 2001

• Fingerlin, T.E., Erdos, M.R., Watanabe, R.M., Valle, T.T., Tuomilehto, J., Bergman, R.N., Boehnke, M., and Collins, F.S., for the FUSION Study Group. Variation in three SNPs in the calpain-10 gene not implicated in conferring susceptibility to type 2 diabetes in a large Finnish cohort. American Journal of Human Genetics 69(Suppl 1):A1831, 2001.
• Li, C, and Boehnke, M. for the Finland-United States Investigation of NIDDM Genetics (FUSION) Study). Association Analysis: Within-Sibship Sampling Variation and Solutions.
• Scott, L.J., Watanabe, R.M., Silander K., Mohlke, K.L., Stringham, H.M., Li, C. Doheny, K., Pugh, E., Valle, T.T., Bergman, R.N., Tuomilehto, J., Collins, F., and Boehnke, M. Quantitative Trait Loci (QTL) Genome Scan in Two Independent Sets of Finnish Affected Sibling Pair Families with Type 2 Diabetes. American Journal of Human Genetics 69(Suppl 1):A196, 2001.
• Silander, K., Steppan, C.M., Mohlke, K.L., Lazaridis, K.N., Valle, T.T., Buchanan, T.A., Watanabe, R.M., Boehnke, M., Tuomilehto, J., Bergman, R.N., Lazar, M.A., and Collins, F.S. Evaluating Resistin as a Susceptibility Gene for Type 2 Diabetes in the Finnish Population. American Journal of Human Genetics 69(Suppl 1):AA2274, 2001.

American Society of Human Genetics 2003

• Conneely, K.N., Silander, K., Lazaridis, K.N., Mohlke, K.L., Scott, L.J., Valle, T.T., Watanabe, R.M., Buchanan, T.A., Bergman, R.N., Tuomilehto, J., Collins, F.S., Boehnke, M. Variation in the Resistin Gene is Associated with Diabetes-Related Phenotypes in Finns.
• Jackson, A.U., Watanabe, R.M., Scott, L.J., Mohlke, K.M., Silander, K., Valle, T.T., Doheny, K., Pugh, E., Tuomilehto, J., Bergman, R.N., Colllins, F.S., Boehnke, M. Evidence for a Free Fatty Acid-Related Diabetes Susceptibility Locus on Chromosome 22 in Finnish Subjects.
• Mohlke, K.L., Silander, K., Peck, E.C., Scott, L.J., Hollstein, P.E., Skol, A.D., Li, C., Chines, P.S., Valle, T.T., Bergman, R.N., Tuomilehto, J., Watanabe, R.M., Boehnke, M., Collins, F.S. Common Non-Coding SNPs near the Hepatocyte Nuclear Factor-4 Alpha Gene are Associated with Type 2 Diabetes.
• Peck, E.C., Mohlke, K.M., Jackson, A.U., Suh, Y., Chines, P.S., Scott, L.J., Tuomilehto, J., Bergman, R.N., Boehnke, M., Collins, F.S., FUSION Study Group. Assessing the Role of the Mitochondrial Genome in Type 2 Diabetes Mellitus and Related Traits in Finns.
• Scott, L.J., Sparks, A.B., Mohlke, K.L., Hinds, D.A., Li, M., Ballinger, D.G., Chines, P.S., Tuomilehto, J., Bergman, R.N., Frazer, K.A., Watanabe, R.M., Collins, F.S., Cox, D.R., Boehnke, M. Pool-based Association Scan for Type 2 Diabetes using 49,419 SNPs in a 92.2 Mb Region on Chromosome 6.

American Society of Human Genetics 2005

• Bonnycastle, L.L., Willer, C.J., Burrill, C.P., Jackson, A.U., Watanabe, R.M., Scott, L.J., Chines, P.S., Conneely, K.N., Narisu, N., Erdos, M.R., Swift, A.J., Riebow, N.L., Enloe, S.T., Buchanan, T.A., Valle, T.T., Tuomilehto, J., Bergman, R.N., Mohlke, K.L., Boehnke, M., Collins, F.S. Type 2 Diabetes (T2D) and Quantitative Trait (QT) Association Analysis of MODY Genes in Finns.

American Society of Human Genetics 2006

• Erdos, M.R., Stringham, H.M., Chines, P.S., Narisu, N., Jackson, A.U., Duren, W.L., Bonnycastle, L.L., Willer, C.J., Scott, L.J., Doheny, K.F., Pugh, E.W., Riebow, N.W., Valle, T.T., Watanabe, R.M., Buchanan, T.A., Bergman, R.N., Tuomilehto, J., Mohlke, K.L., Boehnke, M., Collins, F.S. Evidence for a susceptibility gene for type 2 diabetes on chromosome 11.
• Gaulton, K.J., Conneely, K.N., Li, Y., Jackson, A.U., Scott, L.J., Duren, W.L., Chines, P.S., Narisu, N., Bonnycastle, L., Swift, A., Valle, T.T., Tuomilehto, J., Bergman, R.N., Collins, F.S., Boehnke, M., Mohlke, K.L. Testing for association between type 2 diabetes and 225 candidate genes in 2357 Finnish cases and controls.
• Mohlke, K.L., Jackson, A.U., Scott, L.J., Conneely, K.N., Swift, A., Doheny, K.F., Pugh, E.W., Watanabe, R.M., Abecasis, G.R., Valle, T.T., Tuomilehto, J., Bergman,\ R.N., Collins, F.S., Boehnke, M. Genome-wide association analysis of obesity using 304,968 SNPs in 880 Finnish normal glucose tolerant individuals.
• Willer, C.J., Scott, L.J., Stringham, H.M., Valle, T.T., Rosenberg N.A., Bergman, R.N., Mohlke, K.L., Tuomilehto, J., Collins, F.S., Boehnke, M. Genetic differences across Finland using genomewide SNP data.

American Society of Human Genetics 2007

• Chen, W.M., Jackson, A.U., Scuteri, A., Erdos, M.R., Uda, M., Duren, W.L., Sanns, S., Stringham, H.M., Mulas, A., Shen, H., Scott, L.J., Najjar, S., Shuldiner, A.R., Tuomilehto, J., Lakatta, E., Bergman, R.N., Schlessinger, D., Boehnke, M., Abecasis, G.R., Watanabe, R.M. Genome-wide association scans in cohorts from Sardinia and Finland identify a locus for fasting glucose levels.
• Erdos, M.R., Qin, L., Bonnycastle, L.L., Swift, A.J., Sprau, A.G., Jackson, A.U., Willer, C.J., Yang, C.L., Humphreys, S., Ellison, D.H., Tuomilehto, J., Bergman, R.N., Boehnke, M., Mohlke, K.L., Collins, F.S. Functional analysis of a nonsynonymous coding variant (R325W) in the pancreatic beta-cell specific zinc transporter, SLC30A8, associated with type 2 diabetes.
• Li, Y., Willer, C.J., Ding, J., Scheet, P., Abecasis, G.R. In Silico Genotyping for Genome-Wide Association Studies.
• Sanna, S., Jackson, A.U., Usala, G., Willer, C.J., Dei, M., Bonnycastle, L.L., Lai, S., Li, Y., Uda, M., Erdos, M.R., Shen, H., Shuldiner, A., Cao, A., Bergman, R.N., Schlessinger, D., Collins, F.S., Boehnke, M., Abecasis, G.R., Nagaraja, R., Mohlke, K.L. Genome-wide association scan for height in 6,671 individuals from Finland and Sardinia.
• Willer, C.J., Scuteri, A., Bonnycastle, L.L., Sanna, S., Jackson, A.U., Maschio, A., Duren, W.L., Busonero, F., Pruim, R., Diabetes Genetics Initiative, Watanabe, R.M., Najjar, S.S., Scott, L.J., Uda, M., Tuomilehto, J., Abecasis, G.R., Collins, F.S., Schlessinger, D., Mohlke, K.L., Lakatta, E.G. Genome-wide association scan for HDL cholesterol, LDL cholesterol, and triglyceride levels in 9,000 individuals.

American Society of Human Genetics 2008

• Berndt, S.I., Qi, L., Jackson, A.U., Garcia-Closas, M., Boehnke, M., Hu, F., Hunter, D.J., Chanock, S.J., Hayes, R.B. Meta-analysis of genome-wide association scans reveals new loci for body mass index in early adulthood.
• Langenberg, C., Prokopenko, I., Florez, J., Saxena, R., Thorleifsson, G., Soranzo, N., for MAGIC Institutions: MRC Epidemiology Unit, Cambridge, UK; Oxford Centre for Diabetes, Endocrinology and Metabolism, Oxford, UK; Wellcome Trust Centre for Human Genetics, Oxford, UK; Broad Institute of Harvard and MIT, Cambridge, MA; Department of Medicine, Harvard Medical School, Boston, MA; Center for Human Genetic Research and Diabetes Unit, Massachusetts General Hospital, Boston, MA; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA; deCODE genetics, Reykjavík, Iceland; Wellcome Trust Sanger Institute, Hinxton, UK; Twin Research and Genetic Epidemiology Department, King's College London, London, UK Common variants in MTNR1B (melatonin receptor 1B) influence fasting glucose and type 2 diabetes risk.
• Stitzel, M.L., Deodhar, P., Scott, L.J., Jackson, A.U., Swift, A., Narisu, N., Boehnke, M., Collins, F.S. Assessing regulatory potential and functional consequences of Type 2 diabetes-associated variants on 9p21.

Endocrine Society Meeting 1996

• Hagopian, W.A., Valle, T., Watanabe, R.M., Hauser, E.R., Bergman, R.N. Tuomilehto-Wolf, E., Tuomilehto, J., Ghosh, S., Collins, F., Boehnke, M. and the Finland-United States Investigation of NIDDM Genetics (FUSION) Study Group. Multiple Markers of Autoimmunity Among Apparent NIDDM Subjects in the FUSION Study.

European Association for the Study of Diabetes 1996

• Watanabe, R.M., Hauser, E.R., Valle, T., Eriksson, J., Bergman, R.N., and Boehnke, M. for the Finland-United States Investigation of NIDDM Genetics (FUSION) Study Investigators. Familiality of Quantitative Metabolic Traits in a Finnish Population. Diabetologia 39(Suppl 1):A74, 1996.

European Association for the Study of Diabetes 1997

• Buchanan, T., Watanabe, R.M., Valle, T., Tuomilehto, J., Eriksson, J., and Bergman, R.N. for the Finland-United States Investigation of NIDDM Genetics (FUSION) Study. An Empirical Solution for the Problem of Zero Insulin Sensitivity in Insulin-Resistant Individuals. International Diabetes Monitor 10:A9, 1997. (Satellite symposium of EASD/IDF; Copenhagen, Denmark)
• Ghosh, S., Hauser, E.R., Magnuson, V.L., Ally, D.S., Valle, T., Watanabe, R.M., Nylund, S.J., Kohtamaki, K., Bergman, R.N., Tuomilehto, J., Collins, F.S., and Boehnke, M. for the Finland- United States Investigation of NIDDM Genetics (FUSION) Study. Multipoint Linkage Analysis of NIDDM in 534 Finnish Families in the FUSION Study. Diabetologia 40(Suppl 1):A158, 1997.
• Watanabe, R.M., Hauser, E.R., Valle, T., Eriksson, J., Bergman, R.N., Ghosh, S., and Boehnke, M. for the Finland-United States Investigation of NIDDM (FUSION) Study Investigators. Familiality of Minimal Model-Derived Quantitative Metabolic Traits in a Finnish Cohort. International Diabetes Monitor 10:A7, 1997. (Satellite symposium of EASD/IDF 1997; Copenhagen, Denmark)
• Valle, T., Langefeld, C.D., Hauser, E.R., Watanabe, R.M., Ghosh, S., Kohtamaki, K., Forsen, T., Tuomilehto, J., Buchanan, T.A., and Eriksson, J.G. for the Finland-United States Investigation of NIDDM Genetics (FUSION) Study. Association Between Birth Weight and Adult Metabolic Profile in the Offspring of NIDDM Subjects. Diabetologia 40(Suppl 1):A215, 1997.
• Valle, T., Ghosh, S., Hauser, E.R., Magnuson, V., Ally, D., Watanabe, R.M., Kohtamaki, K., Tuomilehto-Wolf, E., Toivanen, L., Vidgren, G., Hagopian, W., Buchanan, T., Bergman, R.N., Tuomilehto, J., Collins, F., and Boehnke, M. for the Finland-United States Investigation of NIDDM Genetics (FUSION) Study. Search for NIDDM Genes in a Finnish Sample. (Satellite symposium of EASD/IDF 1997; Savonlinna, Finland)

International Genetic Epidemiologic Society 1997

• Ghosh, S., Hauser, E., Magnuson, V., Valle, T., Ally, D., Watanabe, R., Hagopian, W., Bergman, R., Tuomilehto, J., Collins, F., and Boehnke, M. for the FUSION Team. The FUSION (Finland-United States Investigation of NIDDM Genetics) Study.
• 4th International Meeting on Single Nucleotide Polymorphism and Complex Genome Analysis, October 2001, Stockholm, Sweden Mohlke, K., Scott, L., Silander, K., Stringham, H., Erdos, M., Duren, W., Watanabe, R., Valle, T., Tuomilehto, J., Bergman, R., Boehnke, M., and Collins, F. Fine-mapping of a 50-kb region associated with type 2 diabetes in Finns.