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Published Papers (listed alphabetically by first author, most recent year first)
2009
- Kathiresan, S., Willer, C.J., Peloso, G.M., Demissie, S., Musunuru, K., Schadt, E.E.,
Kaplan, L., Bennett, D., Li, Y., Tanaka, T., Voight, B.F., Bonnycastle, L.L., Jackson,
A.U., Crawford, G., Surti, A., Guiducci, C., Burtt, N.P., Parish, S., Clarke, R., Zelenika,
D., Kubalanza, K.A., Morken, M.A., Scott, L.J., Stringham, H.M., Galan, P., Swift, A.J.,
Kuusisto, J., Bergman, R.N., Sundvall, Laakso, M., Ferrucci, L., Scheet, P., Sanna, S.,
Uda, M., Yang, Q., Lunetta, K.L., Dupuis, J., de Bakker, P.I.W., O'Donnell, C.J., Chambers,
J.C., Kooner, J.S., Hercberg, S., Meneton, P., Lakatta, E.G., Scuteri, A., Schlessinger, D.,
Tuomilehto, J., Collins, F.S., Groop, L., Altshuler, D., Collins, R., Lathrop, G.M.,
Melander, O., Salomaa, V., Peltonen, L., Orho-Melander, M., Ordovas, J.M., Boehnke, M.,
Abecasis, G.R., Mohlke, K.L., and Cupples, L.A. (2009)
Common Variants at
30 Loci Contribute to Polygenic Dyslipidemia. Nature Genetics 41(1):56-65.
-
Lindgren, C.M., Heid, I.M., Randall, J.C., Lamina, C., Steinthorsdottir, V., Qi, L., Speliotes,
E.K., Thorleifsson, G., Willer, C.J., Herrera, B.M., Jackson, A.U., Lim, N., Scheet, Pl,
Soranzo, N., Amin, N., Aulchenko, Y.S., Chambers, Y.S., Chambers, J.D., Drong, A., Luan, Jl,
Lyon, H.N., Rivadeneira, F., Sanna, S., Timpson, N.J., Zillikens, M.C., Zhao, J.H., Almgren,
P., Bandinelli, S., Bennett, A.J., Bergman, R.N., Bonnycastle, L.L., Bumpstead, S.J.,
Chanock, S.J., Cherkas, L., Chines, P., Coin, L., Cooper, C., Crawford, G., Doering, A.,
Dominiczak, A., Doney, A.S., Ebrahim, S., Elliott, P., Erdos, M.R., Estrada, K., Ferrucci, L., Fischer G, Forouhi NG, Gieger C, Grallert H, Groves CJ, Grundy S, Guiducci C, Hadley D, Hamsten A, Havulinna AS, Hofman A, Holle R, Holloway JW, Illig T, Isomaa B, Jacobs LC, Jameson K, Jousilahti P, Karpe F, Kuusisto J, Laitinen J, Lathrop GM, Lawlor DA, Mangino M, McArdle WL, Meitinger T, Morken MA, Morris AP, Munroe P, Narisu N, Nordström A, Nordström P, Oostra BA, Palmer CN, Payne F, Peden JF, Prokopenko I, Renström F, Ruokonen A, Salomaa V, Sandhu MS, Scott LJ, Scuteri A, Silander K, Song K, Yuan X, Stringham HM, Swift AJ, Tuomi T, Uda M, Vollenweider P, Waeber G, Wallace C, Walters GB, Weedon MN; Wellcome Trust Case Control Consortium, Witteman JC, Zhang C, Zhang W, Caulfield MJ, Collins FS, Davey Smith G, Day IN, Franks PW, Hattersley AT, Hu FB, Jarvelin MR, Kong A, Kooner JS, Laakso M, Lakatta E, Mooser V, Morris AD, Peltonen L, Samani NJ, Spector TD, Strachan DP, Tanaka T, Tuomilehto J, Uitterlinden AG, van Duijn CM, Wareham NJ, Hugh Watkins; Procardis Consortia, Waterworth DM, Boehnke M, Deloukas P, Groop L, Hunter DJ, Thorsteinsdottir U, Schlessinger D, Wichmann HE, Frayling TM, Abecasis GR, Hirschhorn JN, Loos RJ, Stefansson K, Mohlke KL, Barroso I, McCarthy MI, and the Giant Consortium (2009) Genome wide association scan meta-analysis identifies novel loci influencing adiposity and fat distribution. Public Library of Science Genetics 5:e1000508. PMCID: PMC2695778.
- Lyssenko, V., Nagorny, C.L.F., Erdos, M.R., Wierup, N., Jonsson, A., Spegel, P., Bugliani,
M., Saxena, R., Fex, M., Pulizzi, N., Isomaa, B., Tuomi, T., Nilsson, P., Kuusisto, J.,
Tuomilehto, J., Boehnke, M., Altshuler, D., Sundler, F., Eriksson, J.G., Jackson, A.U.,
Laakso, M., Marchetti, P., Watanabe, R.M., Mulder, H., and Groop, L. (2009)
Common Variant in MTNR1B
Associated with Increased Risk of Type 2 Diabetes and Impaired Early Insulin Secretion.
Nature Genetics 41(1):82-88.
- Prokopenko, I., Langenberg, C., Florez, J.C., Saxena, R., Soranzo, N., Thorleifsson, G.,
Loos, R.J.F., Manning, A.K., Jackson, A.U., Aulchenko, Y., Potter, S.C., Erdos, M.R., Sanna,
S., Hottenga, J-J., Wheeler, E., Kaakinen, M., Lyssenko, V., Chen, W-M., Kourosh, K.,
Beckmann, J.S., Bergman, R.N., Bochud, M., Bonnycastle, L.L., Buchanan, T.A., Cao, A.,
Cervino, A., Coin, L., Collins, F.S., Crisponi, L., de Geus, E.J.C., Dehghan, A., Deloukas,
P., Doney, A.S.F., Elliott, P., Freimer, N., Gateva, V., Herder, C., Hofman, A., Hughes,
T.E., Hunt, S., Illig, T., Inouye, M., Isomaa, B., Johnson, T., Kong, A., Krestyaninova, M.,
Kuusisto, J., Laakso, M., Lim, N., Lindblad, U., Lindgren, C.M., McCann, O.T., Mohlke, K.L.,
Morris, A.D., Naitza, S., Orru, M., Palmer, C.N.A., Pouta, A., Randall, J., Rathmann, W.,
Saramies, J., Scheet, P., Scott, L.J., Scuteri, A., Sharp, S., Sijbrands, E., Smit, J.H.,
Song, K., Steinthorsdottir, V., Stringham, H.M., Tuomi, T., Tuomilehto, J., Uitterlinden,
A.G., Voight, B.F., Waterworth, D., Wichmann, H-E., Willemsen, G., Witteman, J.C.M., Yuan,
X., Zhao, J.H., Zeggini, E., Schlessinger, D., Sandhu, M., Boomsma, D.I., Uda, M., Spector,
T.D., Penninx, B.W.J.H., Altshuler, D., Vollenweider, P., Jarvelin, M.R., Lakatta, E.,
Waeber, G., Fox, C.S., Peltonen8, L., Groop, L.C., Mooser, V., Cupples, L.A.,
Thorsteinsdottir, U., Boehnke, M., Barroso, I., Van Duijn, C., Dupuis, J., Watanabe, R.M.,
Stefansson, K., McCarthy, M.I., Wareham, N.J., Meigs, J.B., and Abecasis, G.R. (2009)
Variants in MTNR1B
Influence Fasting Glucose Levels. Nature Genetics 41(1):77-81.
- Willer, C.J., Speliotes, E.K., Loos, R.J.F., Li, S., Lindgren, C.M., Heid, I.M., Berndt, S.I.,
Elliott, A.L., Jackson, A.U., Lamina, C., Lettre, G., Lim, N., Lyon, H.N., McCarroll, S.A.,
Papadakis, K., Qi, Ll, Randall, J.C., Roccasecca, R.M., Sanna, S., Scheet, P., Weedon, M.N.,
Wheeler, E., Zhao, J.H., Jacobs, L.C., Prokopenko, I., Soranzo, N., Tanaka, T., Timpson,
N.J., Almgren, P., Bennett, A., Bergman, R.N., Bingham, S.A., Bonnycastle, L.L., Brown, M.,
Burtt, N., Chines, P., Coin, L., Collins, F.S., Connell, J.M., Cooper, C., Smith, G.D.,
Dennison, E.M., Deodhar, P., Elliott, P., Erdos, M.R., Estrada, K., Evans, D.M., Gianniny,
O.L., Gieger, C., Gillson, C.J., Guiducci, C., Hackett, R., Hadley, D., Hall, A.S., Havulinna,
A.S., Hebebrand, J., Hofman, A., Isomaa, B., Jacobs, K.B., Johnson, T., Jousilahti, P.,
Jovanovic, Z., Khaw, K-T., Kraft, P., Kuokkanen, M., Kuusisto, J., Laitinen, J., Lakatta,
E.G., Luan, J., Luben, R.N., Mangino, M., McArdle, W.L., Meitinger, T., Mulas, A., Munroe,
P.B., Narisu, N., Ness, A.R., Northstone, K., O'Rahilly, S., Purmann, C., Rees, M.G.,
Ridderstrale, M., Ring, S.M., Rivadeneira, F., Ruokonen, A., Sandhu, M.S., Saramies, J.,
Scott, L.J., Scuteri, A., Silander, K., Sims, M.A., Song, K., Stephens, J., Stevens, S.,
Stringham, H.M., Tung, Y.C.L., Valle, T.T., Van Duijn, C.M., Vimaleswaran, K.S., Vollenweider,
P., Waeber, G., Wallace, C., Watanabe, R.M., Waterworth, D.M., Watkins, N., The Wellcome Trust
Case Control Consortium, Witteman, J.C.M., Zeggini, E., Zhai, G., Zillikens, M.C., Altshuler,
D., Caulfield, M.D., Chanock, S.J., Farooqi, I.S., Ferrucci, L., Guralnik, J.M., Hattersley,
A.T., Hu, F.B., Jarvelin, M.R., Laakso, M., Mooser, V., Ong, K.K., Ouwehand, W.H., Salomaa,
V., Samani, N.J., Spector, T.D., Tuomi, T., Tuomilehto, J., Uda, M., Uitterlinden, A.G.,
Wareham, N.J., Deloukas, P., Frayling, T.M., Groop, L.C., Hayes, R.B., Hunter, D.J., Mohlke,
K.L., Peltonen, L., Schlessinger, D., Strachan, D.P., Wichmann, H-E., McCarthy, M.I., Boehnke,
M., Barroso, I., Abecasis, G.R., and Hirschhorn, J.N. for the GIANT Consortium (2009)
Six New Loci Associated
with Body Mass Index Highlight a Neuronal Influence on Body Weight Regulation.
Nature Genetics 41(1):25-34.
2008
- Chen, W-M, Erdos, M.R., Jackson, A.U., Saxena, R., Sanna, S., Silver, K.D., Timpson,
N.J., Hansen, T., Orrů, M., Piras, M.G., Bonnycastle, L.L., Willer, C.J., Lyssenko, V.,
Shen, H., Kuusisto, J., Ebrahim, S., Sestu, N., Duren, W.L., Spada, M.C., Stringham, H.M.,
Scott, L.J., Olla, N., Swift, A.J., Najjar, S., Mitchell, B.D., Lawlor, D.A., Smith, G.D.,
Ben-Shlomo, Y., Andersen, G., Borch-Johnsen, K., Jřrgensen, T., Saramies, J., Valle, T.T.,
Buchanan, T.A., Shuldiner, A.R., Lakatta, E., Bergman, R.N., Uda, M., Tuomilehto, J.,
Pedersen, O., Cao, A., Groop, L., Mohlke, K.L., Laakso, M., Schlessinger, D., Collins, F.S.,
Altshuler, D., Abecasis, G.R., Boehnke, M., Scuteri, A., Watanabe, R.M. (2008)
Variations in the
G6PC2/ABCB11 Genomic Region are Associated with Fasting Glucose Levels.
Journal of Clinical Investigation 118:2620-2628. Published online 2 June 2008,
doi:10.1172/JCI34566.
- Franks, P.W., Rolandsson, O., Debenham, S.L., Fawcett, K.A., Payne, F., Dina, C.,
Froguel, P., Mohlke, K.L., Willer, C., Olsson, T., Wareham, N.J., Hallmans, G.,
Barroso, I., and Sandhu, M.S. (2008)
Replication of the Association Between Variants in WFS1 and Risk of Type 2 Diabetes in
European Populations Diabetologia51(3):458-463.
- Lettre, G., Jackson, A.U., Gieger, C., Schumacher, F.R., Berndt, S.I., Sanna, S.,
Eyheramendy, S., Voight, B.F., Butler, J.L, Guiducci, C., Illig, T., Hackett, R.,
Heid, I.M., Jacobs, K.B., Lyssenko, V., Uda, M., The Diabetes Genetics Initiative,
FUSION, KORA, The Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening
Trial, The Nurses' Health Study, SardiNIA, Boehnke, M., Chanock, S.J., Groop, L.C.,
Hu, F.B., Isomaa, B., Kraft, P., Peltonen, L., Salomaa, V., Schlessinger, D., Hunter,
D.J., Hayes, R.B., Abecasis, G.R., Wichmann, H-Erich, Mohlke, K.L., and Hirschhorn,
J.N. (2008)
Identification of Ten Loci Associated with Height Highlights New Biological
Pathways in Human Growth, Nature Genetics, 40:584-591. Published
Online 6 April 2008, doi:10.1038/ng.125.
Supplementary Text and Figures
- Loos, R.J.F., Lindgren, C.M., Li, S., Wheeler, E., Zhao, J.H., Prokopenko, I.,
Inouye, M., Freathy, R.M., Attwood, A.P., Beckmann, J.S., Berndt, S.I., The
Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, Bergmann, S.,
Bennett, A.M., Bingham, S.A., Bochud, M., Brown, M., Cauchi, S., Connell, J.M.,
Cooper, C., Smith, G.D., Day, I., Dina, C., De, S., Dermitzakis, E.T., Doney, A.S.,
Elliott, K.S., Elliott, P., Evans, D.M., Farooqi, S., Froguel, P., Ghori, J.,
Groves, J., Gwilliam, R., Hadley, D., Hall, A.S., Hattersley, A.T., Hebebrand, J.
Heid, I.M., KORA, Herrera, B., Hinney, A., Hunt, S.E., Jarvelin, M-R., Johnson, T.,
Jolley, J.D.M., Karpe, F., Keniry, A., Khaw, K-T., Luben, R.N., Mangino, M.,
Marchini, J., McArdle, W., McGinnis, R., Meyre, D., Munroe, P.B., Morris, A.D.,
Ness, A.R., Neville, M.J., Nica, A.C., Ong, K.K., O'Rahilly, S., Owen, K.R.,
Palmer, C.N.A., Papadakis, K., Potter, S., Pouta, A., Qi, L., Nurses' Health
Study, Randall, J.C., Rayner, N.W., Ring, S.M., Sandhu, M.S., Scherag, A., Sims,
M.A., Song, K., Soranzo, N., Speliotes, E.K., Diabetes Genetics Initiative, Syddall,
H.E., Teichmann, S.A., Timpson, N.J., Tobias, J.H., Uda, M., The SardiNIA Study,
Ganz Vogel, C.I., Wallace, C., Waterworth, D.M., Weedon, M.N., The Wellcome Trust
Case Control Consortium, Willer, C.J., FUSION, Wraight, V.L., Yuan, X., Zeggini,
E., Hirschhorn, J.N., Strachan, D.P., Ouwehand, W.H., Caulfield, M.J.,
Samani, N.J., Frayling, T.M., Vollenweider, P., Waeber, G., Mooser, V., Deloukas,
P., McCarthy, M., Wareham, N.J., and Barroso, I. (2008)
Common Variants Near
MC4R are Associated with Fat Mass, Weight, and Risk of Obesity, Nature
Genetics 40:768-775. Published Online 4 May 2008, doi:10.1038/ng.140.
Supplementary
Text and Figures
- Sanna, S., Jackson, A.U., Nagaraja, R., Willer, C.J., Chen, W-M., Bonnycastle, L.L.,
Shen, H., Timpson, N., Lettre, G., Usala, G., Chines, P.S., Stringham, H.M., Scott,
L.J., Dei, M., Lai, S., Albai, G., Crisponi, L., Naitza, S., Doheny, K.F., Pugh, E.W.,
Shlomo, Y.B., Ebrahim, S., Lawlor, D.A., Bergman, R.N., Watanabe, R.M., Uda, M.,
Tuomilehto, J., Coresh, J., Hirschhorn, J.N., Shuldiner, A.R., Schlessinger, D.,
Collins, F.S., Smith, G.D., Boerwinkle, E., Cao, A., Boehnke, M., Abecasis, G.R.,
Mohlke, K.L. (2008) Common
Variants in the GDF5-UQCC Region are Associated with Variation in Human
Height. Nature Genetics 40:198-203. Published online 13 January 2008,
doi:10.1038/ng.74.
Supplemental Material
- Willer, C.J., Sanna, S., Jackson, A.U., Scuteri, A., Bonnycastle, L.L., Clarke, R.,
Heath, S.C., Timpson, N.J., Najjar, S.S., Stringham, H.M., Strait, J., Duren, W.L.,
Maschio, A., Busonero, F., Mulas, A., Albai, G., Swift, A.J., Morken, M.A., Narisu, N.,
Bennett, D., Parish, S., Shen, H., Galan, P., Meneton, P., Hercberg, S., Zelenika, D.,
Chen, W-M., Li, Y., Scott, L.J., Sheet, P.A., Sundvall, J., Watanabe, R.M., Nagaraja,
R., Ebrahim, S., Lawlor, D.A., Ben-Shlomo, Y., Davey-Smith, G., Shuldiner, A.R.,
Collins, R., Bergman, R.N., Uda, M., Tuomilehto, J., Cao, A., Collins, F.S., Lakatta,
E., Lathrop, G.M., Boehnke, M., Schlessinger, D., Mohlke, K.L., Abecasis, G.R. (2008)
Newly Identified Loci that Influence Lipid Concentrations and Risk of Coronary
Artery Disease. Nature Genetics 40:161-169. Published online
13 January 2008, doi:10.1038/ng.76.
Supplemental Material
- Zeggini, E., Scott, L.J., Saxena, R., and Voight, B.F., for the Diabetes
Genetics Replication and Meta-analysis (DIAGRAM) Consortium (2008)
Meta-analysis of Genome-wide Association Data and Large-scale Replication Identifies
Additional Susceptibility Loci for Type 2 Diabetes, Nature Genetics
40:638-645. Published Online 30 March 2008, doi:10.1038/ng.120.
Supplementary Text and Figures
Supplementary Table 5
2007
- Scott, L.J., Mohlke, K.L., Bonnycastle, L.L., Willer, C.J., Li, Y., Duren, W.L.,
Erdos, M.R., Stringham, H.M., Chines, P.S., Jackson, A.U., Prokunina-Olsson L.,
Ding, C.J., Swift, A.J., Narisu, N., Hu, T., Pruim, R., Xiao, R., Li, X.Y.,
Conneely, K.N., Riebow, N.L., Sprau, A.G., Tong, M., White, P.P., Hetrick, K.N.,
Barhnart, M.W., Bark, C.W., Goldstein, J.L., Watkins, L., Xiang, F., Saramies,
J., Buchanan, T.A., Watanabe, R.M., Valle, T.T., Kinnunen, L., Abecasis, G.R., Pugh,
E.W., Doheny, K.F., Bergman, R.N., Tuomilehto, J., Collins, F.S., Boehnke, M. (2007)
A Genome-Wide Association Study
of Type 2 Diabetes in Finns Detects Multiple Susceptibility Variants.
Science 316:1341-1345.
Supplemental Material.
- Shtir, C., Nagakawa, S., Duren, W.L., Conneely, K.N., Scott, L.J., Silander, K.,
Valle, T.T., Tuomilehto, J., Buchanan, T.A., Bergman, R.N., Collins, F.S.,
Boehnke, M., Watanabe, R.M. (2007) Subsets of Finns with High HDL to Total Cholesterol Ratio Show
Evidence to Type 2 Diabetes on Chromosome 6q. Human Heredity 63:17-25.
Willer, C.J., Bonnycastle, L.L., Conneely, K.N., Duren, W.L., Jackson, A.U.,
Scott, L.J., Narisu, N., Chines, P.S., Skol, A., Stringham, H., Petrie, J.,
Erdos, M.R., Swift, A.J., Enloe, S.T., Sprau, A.G., Smith, E., Tong, M.,
Doheny, K.F., Pugh, E.W., Watanabe, R.W., Buchanan, T.A., Valle, T.T.,
Bergman, R.N., Tuomilehto, J., Mohlke, K.L, Collins, F.S., and Boehnke, M.
(2007)
Screening of 134 Single Nucleotide Polymorphisms (SNPs) Previously Associated
with 12 SNPs in Nine Genes. Diabetes 56:256-264.
Online Appendix 1
Online Appendix 2
Online Appendix 3
2006
- Bonnycastle, L.L., Willer, C.J., Conneely, K.N., Jackson, A.U., Burrill, C.P.,
Watanabe, R.M., Chines, P.S., Narisu, N., Scott, L.J., Enloe, S.T., Swift, A.J.,
Duren, W.L., Stringham, H.M., Erdos, M.R., Riebow, N.L., Buchanan, T.A., Valle, T.T.,
Tuomilehto, J., Bergman, R.N., Mohlke, K.L., Boehnke, M., Collins, F.S. (2006)
Common Variants in
Maturity-Onset Diabetes of the Young Genes Contribute to Risk of Type 2 Diabetes in
Finns. Diabetes 55:2534-2540.
- Huth, C., Heid, I.M., Vollmert, C., Gieger, C., Grallert, H., Wolford, J.K.,
Langer, B., Thorand, B., Klopp, N., Hamid, Y.H., Pedersen, O., Hansen, T.,
Lyssenko, V., Groop, L., Meisinger, C., Doring, A., Lowel, H., Lieb, W.,
Hengstenberg, C., Rathmann, W., Martin, S., Stephens, J.W., Ireland, H.,
Mather, H., Miller, G.J., Stringham, H.M., Boehnke, M., Tuomilehto, J.,
Boeing, H., Mohlig, M., Spranger, J., Pfeiffer, A., Wernstedt, I.,
Niklason, A., Lopez-Bermejo, A., Fernandez-Real, J.M., Hanson, R.L., Gallart, L.,
Vendrell, J., Tsiavou, A., Hatziagelaki, E., Humphries, S.E., Wichmann, H.E.,
Herder, C., Illig T. (2006)
IL6 Gene Promoter Polymorphisms and Type 2 Diabetes Joint Analysis of Individual
Participants' Data From 21 Studies. Diabetes 55:2915-2921 (Also
online appendix).
- Scott, L.J., Bonnycastle, L.L., Willer, C.J., Sprau, A.G., Jackson, A.U., Narisu, N.,
Duren, W.L., Chines, P.S., Stringham, H.M., Erdos, M.R., Valle, T.T., Tuomilehto, J.,
Bergman, R.N., Mohlke, K.L., Collins, F.S., Boehnke, M. (2006)
Association of Transcription
Factor 7-Like 2 (TCF7L2) Variants With Type 2 Diabetes in a Finnish Sample.
Diabetes 55:2649-2653.
- Tsuchiya, T., Schwarz, P., del Bosque-Plata, L., Hayes, M.G., Dina, C., Froguel, P.,
Towers, G.W., Fischer, S., Temelkova-Kurktschiev, T., Rietzsch, H., Graessler, J.,
Vcelák, J., Palyzová, D., Selisko, T., Bendlová, B., Schulze, J., Julius, U.,
Hanefeld, M., Weedon, M.N., Evans, J.C., Frayling, T.M., Hattersley, A.T.,
Orho-Melander, M., Groop, L., Malecki, M.T., Hansen, T., Pedersen, O., Fingerlin,
T.E., Boehnke, M., Hanis, C.L., Cox, N.J., and Bell, G.I. (2006)
Association of the
calpain-10 gene with type 2 diabetes in Europeans: results of pooled and
meta-analyses. Molecular Genetics and Metabolism 89:174-184.
-
Willer, C.J., Scott, L.J., Bonnycastle, L.L, Jackson, A.U., Chines, P.,
Pruim, R., Bark, C.W., Tsai, Y., Pugh, E.W., Doheny, K.F., Kinnunen, L.,
Mohlke, K.L., Valle, T.T., Bergman, R.N., Tuomilehto, J., Collins, F.S.,
and Boehnke, M. (2006)
Tag SNP
Selection for Finnish Individuals Based on the CEPH Utah HapMap
Database. Genetic Epidemiology 30:180-190.
2005
- Mohlke, K.L. and Boehnke, M. (2005) The role of HNF4A variants in the risk of type 2 diabetes.
Current Diabetes Reports 5:149-156.
- Mohlke, K.L., Skol, A.D., Scott, L.J., Valle, T.T., Bergman, R.N., Tuomilehto, J.,
Boehnke, M. and Collins, F.S. (2005) Evaluation of SLC2A10 (GLUT10) as a candidate gene for susceptibility
to type 2 diabetes and related traits in Finns. Molecular Genetics and
Metabolism 85:323-327.
- Mohlke, K.L., Jackson, A.U., Scott, L.J., Peck, E.C., Suh, Y.D., Chines, P.S.,
Watanabe, R.M., Buchanan, T.A., Conneely, K.N., Erdos, M.R., Narisu, N., Enloe, S.,
Valle, T.T., Tuomilehto, J., Bergman, R.N., Boehnke, M., Collins, F.S. (2005)
Mitochondrial
polymorphisms and susceptibility to type 2 diabetes-related traits in Finns.
Human Genetics 118:245-254.
2004
- Conneely, K.N., Silander K., Scott, L.J., Mohlke, K.L., Lazaridis, K.N.,
Valle, T.T., Tuomilehto, J., Bergman, R.N., Watanabe, R.M., Buchanan, T.A.,
Collins, F.S., Boehnke, M. (2004) Variation in the Resistin Gene is Associated with Obesity and
Insulin-Related Phenotypes in Finnish Subjects. Diabetologia
47:1782-1788.
- Silander, K., Scott, L.J., Valle, T.T., Mohlke, K.L., Stringham, H.M., Wiles, K.R.,
Duren, W.L., Doheny, K.F., Pugh, E.W., Chines, P., Narisu, N., White, P.P.,
Fingerlin, T.E., Jackson, A.U., Li, C., Ghosh, S., Magnuson, V.L., Colby, K.,
Erdos, M.R., Hill, J.E., Hollstein, P., Humphreys, K.M., Kasad, R.A., Lambert, J.,
Lazaridis, K.N., Lin, G., Morales-Mena, A., Patzkowski, K., Pfahl, C., Porter, R.
Rha, D., Segal, L., Suh, Y.D., Tovar, J., Unni, A., Welch, C., Douglas, J.D.,
Epstein, M.P., Hauser, E.R., Hagopian, W., Buchanan, T.A., Watanabe, R.M.,
Bergman, R.N., Tuomilehto, J., Collins, F.S., and Boehnke, M. (2004)
A Large Set of Finnish Affected
Sibling Pair Families With Type 2 Diabetes Suggests Susceptibility Loci on Chromosomes
6, 11, and 14. Diabetes 53:821-829.
- Silander, K., Mohlke, K.L., Scott, L.J., Peck, E.C., Hollstein, P., Skol, A.D.,
Jackson, A.U., Deloukas, P., Hunt, S., Stavrides, G., Chines, P.S., Erdos, M., R.,
Narisu, N., Conneely, K.N., Li, C., Fingerlin, T.E., Dhanjal, S.K., Valle, T.T.,
Bergman, R.N., Tuomilehto, J., Watanabe, R.M., Boehnke, M., and Collins, F.S. (2004)
Genetic Variation Near
the Hepatocyte Nuclear Factor-4a Gene Predicts Susceptibility to Type 2 Diabetes.
Diabetes 53:1141-1149.
2002
- Fingerlin, T.E., Erdos, M.R., Watanabe, R.M., Wiles, K.R., Stringham,
H.M., Molhke, K.L., Silander, K., Valle, T.T., Buchanan, T.A.,
Tuomilehto, J., Bergman, R.N., Boehnke, M., and Collins, F. (2002)
Variation in Three Single Nucleotide Polymorphisms in the Calpain-10
Gene not Associated with Type 2 Diabetes in a Large Finnish Cohort
Diabetes 51:1644-1648.
- Mohlke, K.L., Erdos, M.R., Scott, L.J., Fingerlin, T.E., Jackson, A.U.,
Silander, K., Hollstein, P., Boehnke, M., and Collins, F.S. (2002)
High-throughput screening for evidence of association by using mass spectrometry
genotyping on DNA pools. PNAS 99:16928-16933.
2001
- Douglas, J.A., Erdos, M.R., Watanabe, R.M., Braun, A., Johnston, C.L.,
Oeth, P., Mohlke, K. L., Valle, T.T., Ehnholm, C., Buchanan, T.,
Bergman, R.N., Collins, F.S., Boehnke, M., and Tuomilehto, J. (2001)
The Peroxisome Proliferator-Activated Receptor-Gamma 2 Pro12Ala Variant:
Association with Type 2 Diabetes and Trait Differences.
Diabetes 50:886-890.
- Mohlke, K.L, Lange, E.M., Valle, T.T., Ghosh, S., Magnuson, V.L., Silander
K., Watanabe, R.M., Chines, P.S., Bergman, R.N., Tuomilehto, J., Collins,
F.S., and Boehnke, M. (2001) Linkage Disequilibrium Between Microsatellite Markers
Extends Beyond 1 cM on Chromosome 20 in Finns.
Genome Research 11:1221-1226.
2000
- Ghosh, S., Watanabe, R.M., Valle, T., Hauser, E.R., Magnuson, V.L.,
Langefeld, C.D., Ally, D.S., Mohlke, K.L., Silander, K.,
Kohtamaki, K., Chines, P., Balow, J., Birznieks, G., Chang, J.,
Eldridge, W., Erdos, M.R., Karanjawala, Z.E., Knapp, J.I.,
Kudelko, K., Martin, C., Morales-Mena, A., Musick, A.,
Musick, T., Pfahl, C., Porter, R., Rayman, J.B., Rha, D., Segal, L.,
Shapiro, S., Sharaf, R., Shurtleff, B., So, A., Tannenbaum, J.,
Te, C., Tovar, J., Unni, A., Welch, C., Whiten, R., Witt, A.,
Blaschak-Harvan, J., Douglas, J.A., Duren, W.L., Epstein, M.P.,
Fingerlin, T.E., Kaleta, H.S., Lange, E.M., Li, C., McEachin, R.C.,
Stringham, H.M., Trager, E., White, P.P., Eriksson, J.,
Toivanen, L., Vidgren, G., Nylund, S.J., Tuomilehto-Wolf, E.,
Ross, E.H., Demirchyan, E., Hagopian, W.A., Buchanan, T.A.,
Tuomilehto, J., Bergman, R.N., Collins, F.S., and Boehnke, M. (2000)
The Finland-United States Investigation of Non-Insulin-Dependent
Diabetes Mellitus Genetics (FUSION) Study. I. An Autosomal Genome
Scan for Genes that Predispose to Type 2 Diabetes.
American Journal of Human Genetics 67:1174-1185.
- Karanjawala, Z.E., Kaariainen, H., Ghosh, S., Tannenbaum, J., Martin, C.,
Ally, D., Tuomilehto, J., Valle, T., and Collins, F.S. (2000) Complete Maternal
Isodisomy of Chromosome 8 in an Individual with an Early-Onset Ileal
Carcinoid Tumor. American Journal of Medical Genetics
93:207-210.
- Watanabe, R.M., Ghosh, S., Langefeld, C.D., Valle, T., Hauser, E.R.,
Magnuson, V.L., Mohlke, K.L., Silander, K., Ally, D.S., Chines, P.,
Blaschak-Harvan, J., Douglas, J.A., Duren, W.L., Epstein, M.P.,
Fingerlin, T.E., Kaleta, H.S., Lange, E.M., Li, C., McEachin, R.C.,
Stringham, H.M., Trager, E., White, P.P., Balow, J., Birznieks, G.,
Chang, J., Eldridge, W., Erdos, M.R., Karanjawala, Z.E., Knapp, J.I.,
Kudelko, K., Martin, C., Morales-Mena, A., Musick, A.,
Musick, T., Pfahl, C., Porter, R., Rayman, J.B., Rha, D., Segal, L.,
Shapiro, S., Sharaf, R., Shurtleff, B., So, A., Tannenbaum, J.,
Te, C., Tovar, J., Unni, A., Welch, C., Whiten, R., Witt, A.,
Kohtamaki, K., Ehnholm, C., Eriksson, J., Toivanen, L., Vidgren, G.,
Nylund, S.J., Tuomilehto-Wolf, E., Ross, E.H., Demirchyan, E.,
Hagopian, W.A., Buchanan, T.A., Tuomilehto, J., Bergman, R.N.,
Collins, F.S., and Boehnke, M. (2000)
The Finland-United States Investigation of Non-Insulin-Dependent
Diabetes Mellitus Genetics (FUSION) Study. II. An Autosomal
Genome Scan for Diabetes-Related Quantitative-Trait Loci.
American Journal of Human Genetics 67:1186-1200.
1999
- Ghosh, S., Langefeld, C.D., Ally, D., Watanabe, R.M., Hauser, E.R.
Magnuson, V.L., Nylund, S.J., Valle, T., Eriksson, J.,
Bergman, R.N., Tuomilehto, J., Collins, F.S., and Boehnke, M.
(1999)
The W64R Variant of the Beta3-Adrenergic Receptor is not
Associated with Type II Diabetes or Obesity in a Large Finnish
Sample. Diabetologia 42:238-244, 1999.
- Ghosh, S., Watanabe, R.M., Hauser, E.R., Valle, T., Magnuson, V.L.,
Erdos, M.R., Langefeld, C.D., Balow, J., Ally, D.S., Kohtamaki, K.,
Chines, P., Birznieks, G., Kaleta, H.S., Musick, A., Te, C.,
Tannenbaum, J., Eldridge, W., Shapiro, S., Martin, C., Witt, A.,
So, A., Chang, J., Shurtleff, B., Porter, R., Kudelko, K.,
Unni, A., Segal, L., Sharaf, R., Blaschak-Harvan, J., Eriksson, J.,
Tenkula, T., Vidgren, G., Ehnholm, C., Tuomilehto-Wolf, E.,
Hagopian, W., Buchanan, T.A., Tuomilehto, J., Bergman, R.N.,
Collins, F.S., and Boehnke, M. (1999)
Type 2 Diabetes: Evidence for Linkage on Chromosome 20 in 716
Finnish affected Sib Pairs.
Proceedings of the National Academy of Sciences
96:2198-2203.
- Watanabe, R.M., Valle, T., Hauser, E.R., Ghosh, S., Eriksson, J.,
Kohtamaki, K., Ehnholm, C., Tuomilehto, J., Collins, F.S.,
Bergman, R.N., and Boehnke, M. for the Finland-United States
Investigation of NIDDM Genetics (FUSION) Study Investigators.
(1999) Familiality of Quantitative
Metabolic Traits in Finnish Families with Non-Insulin Dependent
Diabetes Mellitus. Human Heredity 49:159-168.
1998
- Ghosh, S., Hauser, E.R., Magnuson, V.L, Valle, T., Ally, D.S.,
Karanjawala, Z.E., Rayman, J.B., Knapp, J.I., Musick, A.,
Tannenbaum, J., Te, C., Eldridge, W., Shapiro, S., Musick, T.,
Martin, C., So, A., Witt, A., Blaschak-Harvan, J., Watanabe, R.M.,
Hagopian, W., Eriksson, J., Nylund, S., Kohtamaki, K.,
Tuomilehto-Wolf, E., Toivanen, L., Vidgren, G., Ehnholm, C.,
Bergman, R., Tuomilehto, J., Collins, F.S., and Boehnke, M.
(1998)
A Large Sample of Finnish Diabetic Sib-Pairs Reveals no Evidence
for a NIDDM Susceptibility Locus at 2qter.
Journal of Clinical Investigation 102:704-709.
- Valle, T., Tuomilehto, J., Bergman, R.N., Ghosh, S., Hauser, E.R.,
Eriksson, J., Nylund, S., Kohtamaki, K., Tuomilehto-Wolf, E.,
Toivanen, L., Vidgren, G., Ehnholm, C., Blaschak, J.,
Langefeld, C.D., Watanabe, R.M., Magnuson, V., Ally, D.S.,
Hagopian, W.A., Ross, E., Buchanan, T.A., Collins, F., and Boehnke,
M. (1998)
Mapping Genes for Non-Insulin Dependent Diabetes Mellitus: Design of
the Finland-United States Investigation of NIDDM Genetics (FUSION)
Study. Diabetes Care 21:949-958.
1997
- Ghosh, S., Karanjawala, Z., Hauser, E., Ally, D., Knapp, J., Rayman,
J., Musick, A., Tannenbaum, J., Te, C., Shapiro, S., Eldridge, W.,
Musick, T., Martin, C., Smith, J., Carpten, J., Brownstein, M.,
Powell, J., Whiten, R., Chines, P., Nylund, S., Magnuson, V.,
Boehnke, M., Collins, F., and the FUSION Study Group. (1997)
Methods for Precise Sizing,
Automated Binning of Alleles and Reduction of Error Rates in
Large-Scale Genotyping Using Fluorescently-Labeled
Dinucleotide Markers. Genome Research 7:165-178.
1996
- Magnuson, V.L., Ally, D.S., Nylund, S.J., Karanjawala, Z.E., Rayman,
J.B., Knapp, J.I., Lowe, A.L., Ghosh, S., and Collins, F.S. (1996)
Substrate Nucleotide-Determined Non-Templated Addition of
Adenine by Taq DNA Polymerase: Implications for PCR-Based
Genotyping and Cloning. BioTechniques 21(4):700-709.
FUSION-Related Papers (Published)
2009
- Xiao, R. and Boehnke, M. (2009) Quantifying and correcting for the winner's curse in genetic association studies. Genetic Epidemiology 33:453-462. PMCID: PMC2706290.
- Guan W, Liang L, Boehnke M, and Abecasis GR (2009) Genotype-based matching to correct for population stratification in large-scale case-control genetic association studies. Genetic Epidemiology 33:508-517. PMCID: PMC2732762.
- Salanti G, Southam L, Altshuler D, Ardlie K, Barroso I, Boehnke M, Cornelis MC, Frayling TM, Grallert H, Grarup N, Groop L, Hansen T, Hattersley AT, Hu FB, Hveem K, Illig T, Kuusisto J, Laakso M, Langenberg C, Lyssenko V, McCarthy MI, Morris A, Morris AD, Palmer CN, Payne F, Platou CG, Scott LJ, Voight BF, Wareham NJ, Zeggini E, and Ioannidis JP (2009) Underlying genetic models of inheritance in established type 2 diabetes associations. American Journal of Epidemiology 170:537-545. PMCID: PMC2732984.
2007
2006
- Li, C. and Boehnke, M. (2006)
Haplotype Association Analysis for Late Onset Diseases using Nuclear Family Data.
Genetic Epidemiology 30:220-230.
- Li, M., Boehnke, M., and Abecasis, G.R. GR (2006) Efficient Study Designs for Test of Genetic Association using Sibship
Data and Unrelated Cases and Controls. American Journal of Human Genetics
78:778-792.
- Skol, A.D., Scott, L.J., Abecasis, G.R., and Boehnke, M. (2006)
Joint Analysis is more Efficient
than Replication-based Analysis for Two-stage Genome-wide Association Studies.
Nature Genetics 38:209-213.
2005
2004
- Fingerlin, T.E., Boehnke, M., and Abacesis, G.R. (2004)
Increasing the Power and
Efficiency of Disease-Marker Case-Control Association Studies Through Use of
Allele-Sharing Information. American Journal of Human Genetics 74:432-443.
- Hauser, E.R., Watanabe, R.M., Duren, W.L., Bass, M.P., Langefeld, C.D., and Boehnke, M.
(2004) Ordered Subset Analysis
in Genetic Linkage Mapping of Complex Traits. Genetic Epidemiology 27:53-63.
- Li, C., Scott, L.J., and Boehnke, M. (2004) Assessing Whether an Allele can Account in Part for a Linkage Signal:
The Genotype-IBD Sharing Test (GIST). American Journal of Human Genetics
74:418-431.
2003
1997
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