FUSION (Finland-United States Investigation of NIDDM Genetics) Study

Since its beginning in 1984, the Finland-United States Investigation of NIDDM Genetics (FUSION) Study has sought to extend our understanding of the genetic basis of type 2 diabetes and related traits including glucose, insulin, and lipid levels and body mass index. FUSION is a collaboration between investigators in Helsinki and Kuopio in Finland and Ann Arbor, Bethesda, Chapel Hill, and Los Angeles in the United States.

FUSION has enrolled > 20,000 participants from across Finland, with participants providing clinical and questionnaire data, blood samples for DNA extraction, and (in a subset of individuals) tissue samples for an array of genomic assays.

FUSION investigators conducted one of the first genome-wide association studies (GWAS) of type 2 diabetes, are leaders in GWAS meta-analyses that have assembled data on >1 million participants to identify thousands of genetic loci for type 2 diabetese and diabetes-related traits, and are working to determine the molecular mechanisms underlying the discovered genetic loci. FUSION data are available to approved researchers through dbGaP.